Docetaxel induced pellagroid dematitis

Docetaxel-induced photolichenoid eruption

A 58-year-old man presented with complaints of blackish discoloration of forearms and face of five months duration. The lesions occurred episodically after taking anti-cancer medications, each episode lasting for two weeks. Histopathology confirmed a lichenoid eruption. Photolichenoid eruption to docetaxel is a dermatological adverse effect not reported in literature earlier.

[Docetaxel-induced psoriasis].

Trastuzumab–Docetaxel Combination Chemotherapy Induced Severe Onychopathy

Sir, Taxanes, which are inhibitors of tubulin function in mitosis and used as cancer chemotherapy, are well known to be associated with onychopathy. Trastuzumab, a recombinant DNA‐derived humanized monoclonal antibody against the human epidermal growth factor receptor 2 protein (HER‐2) is used in combination with taxanes in advanced stage HER‐2 positive metastatic breast cancer.[1] We report th...

Docetaxel-induced alopecia can be prevented.

SIR – Taxoids are new antineoplastic drugs that inhibit depolymerisation of tubulin. With docetaxel at 100 mg/m as first line chemotherapy in untreated advanced or metastatic breast cancer patients, an overall response rate of 68% was observed. About 95% of the patients receiving docetaxel 100 mg/m have a grade 3 alopecia. To prevent docetaxelinduced alopecia, we used a cold cap on 39 patients ...

Persistent docetaxel-induced supravenous erythematous eruption*

Taxanes are drugs used to treat many types of cancer, including breast and lung cancer. The most common side effects of these drugs are neutropenia and mucositis. Signs of skin toxicity are observed in about 65% of cases and include alopecia, hypersensitivity reactions, persistent supravenous erythematous eruption, nail changes, scleroderma reactions and others. We report two cases of skin reac...